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TAME,UbiquitinLigaseAPC/CInhibitor

品牌：Xcessbio

貨號：M60246-2s

規(guī)格：2 mg solid

貨期：

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TAME,UbiquitinLigaseAPC/CInhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	378.87
Formula:	C₁₄H₂₂N₄O₄S.HCl
Purity:	≥98%
CAS#:	1784-03-8
Solubility:	DMSO and water up to 100 mM
Chemical Name:	(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract.

How to Use:

In vitro: TAME was used at 50-200 μM final concentration in various in vitro assays.
In vivo: n/a

Reference:

1. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. (2010) Cancer Cell. 18(4):382-95.?
2. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. (2012) Nat Chem Biol. 8(4):383-92.?

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