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IOX1,2OGOxygenasesInhibitor

品牌：Xcessbio

貨號(hào)：M60195-2s

規(guī)格：2mg solid

貨期：

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IOX1,2OGOxygenasesInhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	189.17
Formula:	C₁₀H₇NO₃
Purity:	≥98%
CAS#:	5852-78-8
Solubility:	DMSO up to 100 mM
Chemical Name:	8-hydroxyquinoline-5-carboxylic acid
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. ?It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC₅₀?at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.

How to Use:

In vitro:? IOX1 was used at 10-300 μM final concentration in various in vitro assays.
In vivo:??n/a?

Reference:

1. King ON, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. (2010) PLoS One. 5(11):e15535.
2. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. (2014) ChemMedChem. 9(3):566-71.
3. http://?http://www.thesgc.org/chemical-probes/IOX1

Products are for research use only. Not for human use.

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