間充質(zhì)干細(xì)胞是特征明確的一類**干細(xì)胞。它們有發(fā)育為成熟細(xì)胞的潛在能力而產(chǎn)生脂肪、軟骨、骨骼和肌肉。這些特性與它們發(fā)育中的可塑性共同作用，使人們對(duì)用間充質(zhì)干細(xì)胞來(lái)替換受損組織的潛在能力產(chǎn)生了極大的興趣。間充質(zhì)干細(xì)胞無(wú)血清培養(yǎng)，在轉(zhuǎn)化生長(zhǎng)因子作用下會(huì)分化成軟骨細(xì)胞。相反，在有血清、抗壞血酸和地塞米松的作用下會(huì)分化成成骨細(xì)胞。間充質(zhì)干細(xì)胞有能力更新和分化成多種間充質(zhì)組織。間充質(zhì)干細(xì)胞有潛能被移植到受損傷的部位或者種植到仿生支架上，生長(zhǎng)形成適當(dāng)?shù)慕M織結(jié)構(gòu)。
Sciencell研究實(shí)驗(yàn)室的人脂肪充質(zhì)干細(xì)胞是從人脂肪組織中分離得到的，原代凍存，冰凍運(yùn)輸。每管細(xì)胞密度*過(guò)5×10^5/ml。人脂肪間充質(zhì)干細(xì)胞經(jīng)免疫熒光鑒定、和CD73，CD90，CD105的抗體鑒定，以及分化后的脂質(zhì)染色鑒定。本細(xì)胞經(jīng)檢測(cè)不含HIV-1、HBV、HCV、支原體、細(xì)菌、酵母菌和真菌。如采用ScienCell 實(shí)驗(yàn)室特制的培養(yǎng)基，可保證此細(xì)胞15倍增增殖。
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貨號(hào)
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7510
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產(chǎn)地
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美國(guó)
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縮寫
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HMSC-bm
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規(guī)格
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5 x 10^5 /1ml
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用途
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科研
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儲(chǔ)存
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液氮
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運(yùn)輸
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干冰
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1.) Lee HK, Finniss S, Cazacu S, Bucris E, Ziv-Av A, Xiang C, Bobbitt K, Rempel SA, Hasselbach L, Mikkelsen T, Slavin S, Brodie C. (2013) "Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal." Oncotarget. 4: 346-61.
2.) Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M. (2010) "Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration." J Neuropathol Exp Neurol. 69: 973-85.
3.) Schoolmeesters A, Eklund T, Leake D, Vermeulen A, Smith Q, Force Aldred S, Fedorov Y. (2009) "Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells." PLoS One. 4: e5605.
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