心臟成纖維細(xì)胞為心肌細(xì)胞提供結(jié)構(gòu)支持，并負(fù)責(zé)在生長(zhǎng)和病理生理?xiàng)l件下心肌細(xì)胞外基質(zhì)的合成。CF是心肌損傷反應(yīng)的重要細(xì)胞成分和旁分泌生長(zhǎng)因子的來(lái)源。CF的增殖和基質(zhì)合成對(duì)于心肌梗塞、心肌纖維化部位瘢痕形成具有重要作用。CF的培養(yǎng)已被廣泛應(yīng)用為生理（運(yùn)動(dòng)）和病理（高血壓）應(yīng)激下心臟基質(zhì)重塑研究的模型。
Sciencell研究實(shí)驗(yàn)室的HCF-av是從**心室分離得到的，原代凍存，冰凍運(yùn)輸。每管細(xì)胞密度*過(guò)5×10^5/ml。細(xì)胞特性經(jīng)纖維粘連蛋白免疫熒光鑒定。本細(xì)胞經(jīng)檢測(cè)不含HIV-1、HBV、HCV、支原體、細(xì)菌、酵母菌和真菌。如采用ScienCell 實(shí)驗(yàn)室特制的培養(yǎng)基，可保證此細(xì)胞15倍增增殖。
推薦培養(yǎng)基：成纖維細(xì)胞培養(yǎng)基 (FM, Cat. #2301)
|
貨號(hào)
|
6310
|
|
產(chǎn)地
|
美國(guó)
|
|
縮寫
|
HCF-av
|
|
規(guī)格
|
5 x 10^5 /1ml
|
|
用途
|
科研
|
|
儲(chǔ)存
|
液氮
|
|
運(yùn)輸
|
干冰
|
1.) Watson CJ, Ledwidge MT, Phelan D, Collier P, Byrne JC, Dunn MJ, McDonald KM, Baugh JA. (2011) "Proteomic Analysis of Coronary Sinus Serum Reveals Leucine-Rich {alpha}2-Glycoprotein as a Novel Biomarker of Ventricular Dysfunction and Heart Failure." Circ Heart Fail. 4: 188-97.
2.) Chen JB, Tao R, Sun HY, Tse HF, Lau CP, Li GR. (2010) "Multiple Ca2+ signaling pathways regulate intracellular Ca2+ activity in human cardiac fibroblasts." J Cell Physiol. 223: 68-75.
3.) Li GR, Sun HY, Chen JB, Zhou Y, Tse HF, Lau CP. (2009) "Characterization of multiple ion channels in cultured human cardiac fibroblasts." PLoS One. 4: e7307.
4.) Bunda S, Liu P, Wang Y, Liu K, Hinek A. (2007) "Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner." Am J Pathol. 171: 809-19.
There are no product questions yet.
