心臟微血管內皮細胞（CMEC）在心肌功能中發(fā)揮重要作用。CEMC能夠調節(jié)血管張力，這一作用通過釋放和降解內皮源性血管活性物質、以酶促作用調節(jié)局部縮血管物質和舒血管物質水平實現(xiàn)。些物質中的許多還可以調節(jié)心肌的收縮行為。此外，微血管已被證明參與白細胞聚集，炎癥和血管生成的調控。他們也能轉分化為肌成纖維細胞，提示的作用，提示其作用與細胞外基質異常聚集和纖維化病變有關。CMEC的體外培養(yǎng)是一種可視的工具用來研究CMEC心臟功能和疾病的生理學以及病理生理學。
Sciencell研究實驗室的CMEC是從人心臟分離得到的，原代凍存，冰凍運輸。每管細胞密度*過5×10^5/ml。細胞特性經(jīng)vWF/Factor VIII和CD31 (P-CAM) 免疫熒光鑒定，能夠攝取DiI標記乙酰化低密度脂蛋白(DiI-Ac-LDL)。本細胞經(jīng)檢測不含HIV-1、HBV、HCV、支原體、細菌、酵母菌和真菌。如采用ScienCell 實驗室特制的培養(yǎng)基，可保證此細胞10倍增增殖。
推薦培養(yǎng)基：內皮細胞培養(yǎng)基 (ECM, Cat. #1001)
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貨號
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6000
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產(chǎn)地
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美國
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縮寫
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HCMEC
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規(guī)格
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5 x 10^5 /1ml
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用途
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科研
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儲存
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液氮
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運輸
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干冰
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6.) Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Valente AJ, Chandrasekar B. (2008) "Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death." Free Radic Biol Med. 44: 284-98.
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