氣道平滑肌是維持氣道張力的根本。它存在于氣管、支氣管樹直至終末支氣管。其特異的*微結(jié)構(gòu)特點(diǎn)和調(diào)節(jié)機(jī)制是實(shí)現(xiàn)氣管正常生理功能的基礎(chǔ)。有證據(jù)表明氣管平滑肌在肺的發(fā)育過程以及諸如**病、慢性****和肺氣腫等疾病狀態(tài)下經(jīng)歷著顯著的表型變化。另外，氣道平滑肌通過分泌細(xì)胞因子和趨化因子等促炎介質(zhì)，發(fā)揮免疫調(diào)節(jié)功能。培養(yǎng)的氣管平滑肌細(xì)胞能表達(dá)三種P21活化的激酶（PAK）的同型異構(gòu)體和PAK1，并通過P38 mapk信號途徑參與氣管平滑肌細(xì)胞的遷移。氣道平滑肌細(xì)胞增殖已成為人們關(guān)注的焦點(diǎn)，因?yàn)樵?*病人中，此細(xì)胞是氣道壁重塑反應(yīng)中數(shù)量上的重要組分，并被認(rèn)為是新型抗**病藥物的作用目標(biāo)。
人氣管平滑肌細(xì)胞提取于人氣管組織，二代凍存。每管含有細(xì)胞數(shù)>5×105 cells/ml，此細(xì)胞通過對alpha-SMA和Desmin免疫熒光染色驗(yàn)證，經(jīng)測試不含有HIV-1、HBV、HCV、支原體、細(xì)菌、酵母和真菌。細(xì)胞可以達(dá)到15倍增。? ?
推薦培養(yǎng)基：平滑肌細(xì)胞培養(yǎng)基 (SMCM, Cat. #1101)
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貨號
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3410
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產(chǎn)地
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美國
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縮寫
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HTSMC
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規(guī)格
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5 x 10^5 /1ml
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用途
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科研
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儲存
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液氮
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運(yùn)輸
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干冰
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