人肺泡上皮細胞由肺泡I型和Ⅱ型上皮細胞組成，線性分布于肺內(nèi)99%以上的表面積。肺泡I型細胞是一種大而扁平細胞，其稀薄的細胞質延展占據(jù)了其內(nèi)表面積的95%以上。它含有水通道，是所有哺乳動物細胞中水滲透性*高的細胞。肺泡Ⅱ型上皮細胞只占據(jù)了2-5%的面積，它能產(chǎn)生，分泌并再利用肺表面活性物質。肺泡Ⅱ型上皮細胞同時含有Na+-K+-ATP酶和阿米洛利敏感的上皮細胞Na+通道。目前被普遍接受的假說是肺泡Ⅱ型上皮細胞通過調節(jié)肺Na+傳遞的活性來維持著肺液體內(nèi)環(huán)境穩(wěn)定平衡，而肺泡I型細胞是無活性的細胞，僅提供屏障功能而無活化功能。新近的研究表明肺泡I型在調節(jié)離子和液體轉運過程中也具有重要作用。
人肺泡上皮細胞提取于人肺組織，原代凍存。每管含有細胞數(shù)>1×10^6 cells/ml，此細胞通過Cytokeratin-18, -19和Vimentin免疫熒光染色驗證，經(jīng)測試不含有HIV-1、HBV、HCV、支原體、細菌、酵母和真菌。
推薦培養(yǎng)基：上皮細胞培養(yǎng)基 (EpiCM, Cat. #4101)
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貨號
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3200
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產(chǎn)地
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美國
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縮寫
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HPAEpiC
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規(guī)格
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1 x 10^6 /1ml
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用途
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科研
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儲存
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液氮
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運輸
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干冰
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