成纖維細(xì)胞是間葉細(xì)胞，它在成熟的生物體發(fā)育過程中具有許多重要的功能。成纖維細(xì)胞與結(jié)締組織中細(xì)胞外基質(zhì)的合成有關(guān)，并且在創(chuàng)傷**過程中起著重要作用。許多疾病都與成纖維細(xì)胞有關(guān)，不僅因為成纖維細(xì)胞與病原論有關(guān)，而且纖維癥伴隨著組織中其它細(xì)胞類型的損害。成纖維細(xì)胞是*易獲得的哺乳動物細(xì)胞類型而且*適于體外培養(yǎng)。牙齦成纖維細(xì)胞是牙齦組織中的主要成分，并在維持牙齦健康中起著關(guān)鍵作用。人牙齦纖維原細(xì)胞表達(dá)廣泛的表面分子，主要包括CD9, CD26, CD55, CD59, CD63, CD71, CD86 CD95, CD99和CD117。也有證據(jù)表明牙齦成纖維細(xì)胞為蛋白酶激活受體1和蛋白酶激活受體3表達(dá)mRNA。
推薦培養(yǎng)基：成纖維細(xì)胞培養(yǎng)基 (FM, Cat. #2301)
|
貨號
|
2620
|
|
產(chǎn)地
|
美國
|
|
縮寫
|
HGnF
|
|
規(guī)格
|
5 x 10^5 /1ml
|
|
用途
|
科研
|
|
儲存
|
液氮
|
|
運輸
|
干冰
|
1.) Herath TDK, Darveau RP, Seneviratne CJ, Wang C, Wang Y, Jin L. (2013) "Tetra- and penta-acylated lipid A structures of porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-B signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts." PLoS One. 8: e58496.
2.) Herath TDK, Wang Y, Seneviratne CJ, Darveau RP, Wang C, Jin L. (2013) "The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts." BMC Microbiol. 13: 73.
3.) Zhang K, Cheng L, Imazato S, Antonucci JM, Lin NJ, Lin-Gibson S, Bai Y, Xu HHK. (2013) "Effects of dual antibacterial agents MDPB and nano-silver in primer on microcosm biofilm, cytotoxicity and dentin bond properties." J Dent. 41: 464-74.
4.) Mitsak AG, Kemppainen JM, Harris MT, Hollister SJ. (2011) "Effect of polycaprolactone scaffold permeability on bone regeneration in vivo." Tissue Eng Part A. 17: 1831-9.
5.) Semlali A, Leung KP, Curt S, Rouabhia M. (2011) "Antimicrobial decapeptide KSL-W attenuates Candida albicans virulence by modulating its effects on Toll-like receptor, human beta-defensin, and cytokine expression by engineered human oral mucosa." Peptides. 32: 859-67.
6.) Kim DS, Kim JH, Lee GH, Kim HT, Lim JM, Chae SW, Chae HJ, Kim HR. (2010) "p38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stress-induced cell death and autophagy in human gingival fibroblasts." Biol Pharm Bull. 33: 545-9.
7.) Kioi M, Shimamura T, Nakashima H, Hirota M, Tohnai I, Husain SR, Puri RK. (2009) "IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma." Int J Cancer. 124: 1440-8.
