The antibody detects endogenous level of total FANCC protein.
Applications:
WB, IHC, IF
Reactivity:
Human
Immunogen:
Recombinant protein of human FANCC.
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Purification:
Antibodies were purified by affinity purification using immunogen.
Concentration:
1.0mg / ml
Formulation:
Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:
Store at -20?C
Target
Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Tissue Specificity:
Ubiquitous.
Involvement in Disease:
Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Cellular Location:
Nucleus. Cytoplasm.
The major form is nuclear. The minor form is cytoplasmic.
Database Links:
Entrez Gene: 2176?Human
Omim: 613899?Human
SwissProt: Q00597?Human
Unigene: 494529?Human
Synonyms:
bA80I15.1 Antibody
FA 3 Antibody
FA3 Antibody
FAC Antibody
FACC Antibody
FANCC Antibody
FANCC_HUMAN Antibody
Fanconi anemia complementation group C Antibody
Fanconi anemia complementation group C protein Antibody
Fanconi anemia group C protein Antibody
Fanconi pancytopenia type 3 Antibody
FLJ14675 Antibody
Protein FACC Antibody
Information:
Target information shown above is from the UniProt Consortium.