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Anti-FADD (Phospho-Ser190) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-FADD (Phospho-Ser190) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-FADD (Phospho-Ser190) Antibody See all FADD primary antibodies
Description:	Rabbit polyclonal antibody to FADD (Phospho-Ser190)
Specificity:	The antibody detects endogenous levels of FADD only when phosphorylated at serine 190.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100
Reactivity:	Human, Mouse
Immunogen:	Peptide sequence around phosphorylation site of Serine190(N-R-S(p)-G-A) derived from Mouse FADD.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Specificity:	Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Involvement in Disease:	Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
Database Links:	Entrez Gene: 8772?Human Entrez Gene: 14082?Mouse Omim: 602457?Human SwissProt: Q13158?Human SwissProt: Q61160?Mouse Unigene: 86131?Human Unigene: 5126?Mouse
Synonyms:	FADD Antibody FADD protein Antibody FADD_HUMAN Antibody Fas (TNFRSF6) associated via death domain Antibody Fas associated via death domain Antibody Fas associating death domain containing protein Antibody Fas associating protein Antibody Fas associating protein with death domain Antibody Fas TNFRSF6 associated via death domain Antibody FAS-associated death domain protein Antibody FAS-associating death domain-containing protein Antibody GIG 3 Antibody GIG3 Antibody Growth inhibiting gene 3 protein Antibody Growth-inhibiting gene 3 protein Antibody H sapiens mRNA for mediator of receptor induced toxicity Antibody Mediator of receptor induced toxicity Antibody MGC8528 Antibody MORT 1 Antibody MORT1 Antibody Protein FADD Antibody
Information:	Target information shown above is from the UniProt Consortium.