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Anti-Ezrin (S539) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Ezrin (S539) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Ezrin (S539) Antibody See all Ezrin primary antibodies
Description:	Rabbit polyclonal antibody to Ezrin (S539)
Specificity:	Ezrin/Villin-2 (S539) pAb detects endogenous levels of Ezrin/Villin-2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 500-550 of Human Ezrin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 69, 81 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Tissue Specificity:	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.
Post-Translational Modification:	Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
Cellular Location:	Apical cell membrane. Cell projection. Cell projection > Microvillus membrane. Cell projection > Ruffle membrane. Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton. Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
Database Links:	Entrez Gene: 7430?Human Entrez Gene: 22350?Mouse Entrez Gene: 54319?Rat Omim: 123900?Human SwissProt: P15311?Human SwissProt: P26040?Mouse SwissProt: P31977?Rat Unigene: 487027?Human Unigene: 277812?Mouse Unigene: 773?Rat
Synonyms:	Villin 2 ezrin Antibody CVIL Antibody CVL Antibody Cytovillin Antibody Cytovillin 2 Antibody DKFZp762H157 Antibody Epididymis secretory protein Li 105 Antibody EZR Antibody Ezrin Antibody EZRI_HUMAN Antibody FLJ26216 Antibody HEL S 105 Antibody MGC1584 Antibody p81 Antibody VIL 2 Antibody VIL2 Antibody Villin 2 Antibody Villin 2 (ezrin) Antibody Villin-2 Antibody Villin2 Antibody
Information:	Target information shown above is from the UniProt Consortium.