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Anti-EZH2 Antibody

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Anti-EZH2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Target

Function:	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
Tissue Specificity:	Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.
Involvement in Disease:	Weaver syndrome: A syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly. Distinguishing features of Weaver syndrome include broad forehead and face, ocular hypertelorism, prominent wide philtrum, micrognathia, deep horizontal chin groove, and deep-set nails. In addition, carpal bone development is advanced over the rest of the hand.
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
Post-Translational Modification:	Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 2146?Human Entrez Gene: 14056?Mouse Entrez Gene: 312299?Rat Omim: 601573?Human SwissProt: Q15910?Human SwissProt: Q61188?Mouse Unigene: 444082?Human Unigene: 246688?Mouse Unigene: 9027?Rat
Synonyms:	Enhancer of zeste 2 Antibody enhancer of zeste 2 polycomb repressive complex 2 subunit Antibody Enhancer of zeste homolog 2 Antibody Enhancer of zeste homolog 2 (Drosophila) Antibody Enhancer of zeste, Drosophila, homolog 2 Antibody ENX 1 Antibody Enx 1h Antibody ENX-1 Antibody ENX1 Antibody Enx1h Antibody EZH 2 Antibody EZH1 Antibody EZH2 Antibody EZH2b Antibody EZH2_HUMAN Antibody Histone-lysine N-methyltransferase EZH2 Antibody KMT 6 Antibody KMT6 Antibody KMT6 / EZH2 Antibody KMT6A Antibody Lysine N-methyltransferase 6 Antibody MGC9169 Antibody WVS Antibody WVS2 Antibody
Information:	Target information shown above is from the UniProt Consortium.