| Function: |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
| Tissue Specificity: |
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
| Involvement in Disease: |
Hereditary diffuse gastric cancer: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.
Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Ovarian cancer: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Lung cancer: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. |
| Sequence Similarities: |
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. |
| Post-Translational Modification: |
Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172). |
| Cellular Location: |
Cell membrane. Cytoplasm > Perinuclear region. Nucleus.
Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. |
| Database Links: |
Entrez Gene: 2064?HumanEntrez Gene: 13866?MouseEntrez Gene: 24337?RatOmim: 164870?HumanSwissProt: P04626?HumanSwissProt: P70424?MouseSwissProt: P06494?RatUnigene: 446352?HumanUnigene: 290822?MouseUnigene: 93966?Rat |
| Synonyms: |
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog AntibodyC erb B2/neu protein AntibodyCD340 AntibodyCD340 antigen AntibodyCerb B2/neu protein AntibodyCerbB2 AntibodyErb b2 receptor tyrosine kinase 2 AntibodyErbB 2 AntibodyERBB2 AntibodyERBB2_HUMAN AntibodyHER 2 AntibodyHER 2/NEU AntibodyHER2 AntibodyHerstatin AntibodyHuman epidermal growth factor receptor 2 AntibodyMetastatic lymph node gene 19 protein AntibodyMLN 19 AntibodyMLN19 AntibodyNEU AntibodyNEU proto oncogene AntibodyNeuro/glioblastoma derived oncogene homolog AntibodyNeuroblastoma/glioblastoma derived oncogene homolog AntibodyNGL Antibodyp185erbB2 AntibodyProto-oncogene c-ErbB-2 AntibodyProto-oncogene Neu AntibodyReceptor tyrosine-protein kinase erbB-2 AntibodyTKR1 AntibodyTyrosine kinase type cell surface receptor HER2 AntibodyTyrosine kinase-type cell surface receptor HER2 AntibodyV erb b2 avian erythroblastic leukemia viral oncogene homolog 2 AntibodyV erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) AntibodyV erb b2 avian erythroblastic leukemia viral oncoprotein 2 AntibodyV erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog AntibodyV erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) AntibodyVerb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
