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Anti-Ephrin-B3 (W251) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Ephrin-B3 (W251) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Ephrin-B3 (W251) Antibody See all Ephrin-B3 primary antibodies
Description:	Rabbit polyclonal antibody to Ephrin-B3 (W251)
Specificity:	Ephrin-B3 (W251) pAb detects endogenous levels of Ephrin-B3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 220-272of Human Ephrin-B3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 36 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Tissue Specificity:	Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
Sequence Similarities:	Belongs to the ephrin family.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 1949?Human Entrez Gene: 13643?Mouse Entrez Gene: 360546?Rat Omim: 602297?Human SwissProt: Q15768?Human SwissProt: O35393?Mouse Unigene: 26988?Human Unigene: 249637?Mouse
Synonyms:	EFL 6 Antibody EFL6 Antibody EFNB 3 Antibody Efnb3 Antibody EFNB3_HUMAN Antibody EPH related receptor transmembrane ligand ELK L3 Antibody EPH related receptor transmembrane ligand ELKL3 Antibody EPH related receptor tyrosine kinase ligand 8 Antibody EPH-related receptor transmembrane ligand ELK-L3 Antibody EPH-related receptor tyrosine kinase ligand 8 Antibody Ephrin B3 Antibody Ephrin-B3 Antibody EphrinB3 Antibody EPLG 8 Antibody EPLG8 Antibody LERK 8 Antibody LERK-8 Antibody LERK8 Antibody
Information:	Target information shown above is from the UniProt Consortium.