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Anti-Ephrin-B2 (Ab-330) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Ephrin-B2 (Ab-330) Antibody

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Overview

Name:	Anti-Ephrin-B2 (Ab-330) Antibody See all Ephrin-B2 primary antibodies
Description:	Rabbit polyclonal antibody to Ephrin-B2 (Ab-330)
Specificity:	The antibody detects endogenous level of total Ephrin-B2 protein.
Applications:	WB, IF
Dilutions:	Western blotting: 1:500~1:1000 Immunofluorescence: 1:100~1:200
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around aa.328~332 (N-I-Y-Y-K) derived from Human Ephrin B (ephrin-B2).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:	1.0mg / ml
Predicted MW:	37kd
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Tissue Specificity:	Lung and kidney.
Sequence Similarities:	Belongs to the ephrin family.
Post-Translational Modification:	Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 1948?Human Entrez Gene: 13642?Mouse Entrez Gene: 306636?Rat Omim: 600527?Human SwissProt: P52799?Human SwissProt: P52800?Mouse Unigene: 149239?Human Unigene: 209813?Mouse
Synonyms:	EFN B2 Antibody EFNB 2 Antibody Efnb2 Antibody EFNB2_HUMAN Antibody Eph related receptor tyrosine kinase ligand 5 Antibody EPH-related receptor tyrosine kinase ligand 5 Antibody Ephrin B2 Antibody Ephrin-B2 Antibody EphrinB2 Antibody EPLG 5 Antibody EPLG5 Antibody Htk L Antibody HTK ligand Antibody HTK-L Antibody HTKL Antibody LERK 5 Antibody LERK-5 Antibody LERK5 Antibody Ligand of eph related kinase 5 Antibody MGC126226 Antibody MGC126227 Antibody MGC126228 Antibody OTTMUSP00000024973 Antibody
Information:	Target information shown above is from the UniProt Consortium.