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Anti-EphA1 (F568) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-EphA1 (F568) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EphA1 (F568) Antibody See all EphA1 primary antibodies
Description:	Rabbit polyclonal antibody to EphA1 (F568)
Specificity:	EphA1 (F568) pAb detects endogenous levels of EphA1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 550-600 of Human EphA1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 108 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Tissue Specificity:	Overexpressed in several carcinomas.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-Translational Modification:	Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 2041?Human Entrez Gene: 13835?Mouse Entrez Gene: 312279?Rat Omim: 179610?Human SwissProt: P21709?Human SwissProt: Q60750?Mouse Unigene: 89839?Human Unigene: 133330?Mouse Unigene: 218221?Rat
Synonyms:	EPH Antibody Eph receptor A1 Antibody EPH tyrosine kinase Antibody EPH tyrosine kinase 1 Antibody Epha1 Antibody EPHA1_HUMAN Antibody Ephrin receptor Eph A1 Antibody Ephrin type A receptor 1 Antibody Ephrin type-A receptor 1 Antibody EPHT Antibody EPHT 1 Antibody EPHT1 Antibody Erythropoietin producing hepatoma amplified sequence Antibody Erythropoietin-producing hepatoma receptor Antibody Esk Antibody hEpha1 Antibody MGC163163 Antibody Oncogene EPH Antibody Soluble EPHA1 variant 1 Antibody Soluble EPHA1 variant 2 Antibody Tyrosine protein kinase receptor EPH Antibody Tyrosine-protein kinase receptor EPH Antibody
Information:	Target information shown above is from the UniProt Consortium.