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Anti-Endo180 (G145) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Endo180 (G145) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Endo180 (G145) Antibody See all Endo180 primary antibodies
Description:	Rabbit polyclonal antibody to Endo180 (G145)
Specificity:	Endo180 (G145) pAb detects endogenous levels of Endo180 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 114-160 of Human Endo180.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 167 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Tissue Specificity:	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
Post-Translational Modification:	N-glycosylated.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 9902?Human Entrez Gene: 17534?Mouse Entrez Gene: 498011?Rat Omim: 612264?Human SwissProt: Q9UBG0?Human SwissProt: Q64449?Mouse SwissProt: Q4TU93?Rat Unigene: 7835?Human Unigene: 235616?Mouse Unigene: 213511?Rat
Synonyms:	C-type lectin domain family 13 member E Antibody C-type mannose receptor 2 Antibody CD 280 Antibody CD280 Antibody CD280 antigen Antibody CLEC 13E Antibody CLEC13E Antibody ENDO 180 Antibody ENDO180 Antibody Endocytic receptor (macrophage mannose receptor family) Antibody Endocytic receptor 180 Antibody FLJ35911 Antibody KIAA0709 Antibody Macrophage mannose receptor 2 Antibody Mannose receptor C type 2 Antibody MRC 2 Antibody MRC2 Antibody MRC2_HUMAN Antibody UPAR-associated protein Antibody UPARAP Antibody Urokinase plasminogen activator receptor associated protein Antibody Urokinase receptor associated protein Antibody Urokinase receptor-associated protein Antibody Urokinase-type plasminogen activator receptor-associated protein Antibody
Information:	Target information shown above is from the UniProt Consortium.