麻花豆传媒剧国产MV在线观看,凶猛的办公室高清在线播放

您好，歡迎來到拜力生物網(wǎng)站！請(qǐng)登錄注冊(cè)

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時(shí)間：08:30-17:30

主營產(chǎn)品： ELISA試劑盒、抗體、補(bǔ)體血清、兔補(bǔ)體、干擾素、小鼠測(cè)溫儀、進(jìn)口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁 > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-EMP2 Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：100μl

貨期：

應(yīng)用：

咨詢客服

立即購買加入購物車

Anti-EMP2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EMP2 Antibody See all EMP2 primary antibodies
Description:	Rabbit polyclonal antibody to EMP2
Specificity:	The antibody detects endogenous levels of total EMP2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human epithelial membrane protein 2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).
Tissue Specificity:	Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941).
Involvement in Disease:	Nephrotic syndrome 10: A form of nephrotic syndrome, a renal disease clinically characterized by focal segmental glomerulosclerosis, progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. NPHS10 is a steroid-sensitive form characterized by onset in childhood and remission without end-stage kidney disease.
Sequence Similarities:	Belongs to the PMP-22/EMP/MP20 family.
Cellular Location:	Golgi apparatus membrane. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus. Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane.
Database Links:	Entrez Gene: 2013?Human Omim: 602334?Human SwissProt: P54851?Human Unigene: 531561?Human
Synonyms:	EMP 2 Antibody EMP-2 Antibody EMP2 Antibody EMP2_HUMAN Antibody Epithelial membrane protein 2 Antibody Protein XMP Antibody
Information:	Target information shown above is from the UniProt Consortium.