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Anti-ELOVL1 (F139) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ELOVL1 (F139) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-ELOVL1 (F139) Antibody See all ELOVL1 primary antibodies
Description:	Rabbit polyclonal antibody to ELOVL1 (F139)
Specificity:	ELOVL1 (F139) pAb detects endogenous levels of ELOVL1 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 104-156 of Human ELOVL1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the ELO family. ELOVL1 subfamily.
Cellular Location:	Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 64834?Human Entrez Gene: 54325?Mouse Omim: 611813?Human SwissProt: Q9BW60?Human SwissProt: Q9JLJ5?Mouse Unigene: 25597?Human Unigene: 282096?Mouse
Synonyms:	3 keto acyl CoA synthase ELOVL1 Antibody 3-keto acyl-CoA synthase ELOVL1 Antibody CGI 88 Antibody Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 1 Antibody Elongation of very long chain fatty acids like 1 Antibody Elongation of very long chain fatty acids protein 1 Antibody ELOV1_HUMAN Antibody ELOVL 1 Antibody ELOVL FA elongase 1 Antibody ELOVL fatty acid elongase 1 Antibody ELOVL1 Antibody Ssc1 Antibody Ssc1, mouse, homolog of Antibody very long chain 3 oxoacyl CoA synthase 1 Antibody Very-long-chain 3-oxoacyl-CoA synthase 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.