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Anti-Elk-1 (Phospho-Ser383) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Elk-1 (Phospho-Ser383) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Elk-1 (Phospho-Ser383) Antibody See all Elk1 primary antibodies
Description:	Rabbit polyclonal antibody to Elk-1 (Phospho-Ser383)
Specificity:	The antibody detects endogenous level of Elk-1 only when phosphorylated at serine 383.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of serine 383 (T-L-S(p)-P-I) derived from Human Elk-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Tissue Specificity:	Lung and testis.
Sequence Similarities:	Belongs to the ETS family.
Post-Translational Modification:	Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 2002?Human Entrez Gene: 13712?Mouse Entrez Gene: 314436?Rat Omim: 311040?Human SwissProt: P19419?Human SwissProt: P41969?Mouse SwissProt: A4GTP4?Rat Unigene: 181128?Human Unigene: 405823?Mouse Unigene: 203416?Rat
Synonyms:	ELK 1 Antibody ELK1 Antibody ELK1 member of ETS oncogene family Antibody ELK1 protein Antibody ELK1, ETS transcription factor Antibody ELK1_HUMAN Antibody ELK2 member of ETS oncogene family Antibody ETS domain containing protein Elk 1 Antibody ETS domain containing protein Elk1 Antibody ETS domain protein Elk1 Antibody ETS domain-containing protein Elk-1 Antibody ETS like gene 1 Antibody Member of ETS oncogene family Antibody Oncogene Elk1 Antibody Tyrosine kinase (ELK1) oncogene Antibody
Information:	Target information shown above is from the UniProt Consortium.