婷婷激情综合开心,亚洲激情五月,97SE亚洲国产综合自在线不卡

您好，歡迎來到拜力生物網(wǎng)站！請登錄注冊

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時(shí)間：08:30-17:30

主營產(chǎn)品： ELISA試劑盒、抗體、補(bǔ)體血清、兔補(bǔ)體、干擾素、小鼠測溫儀、進(jìn)口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁 > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-EFNA1 Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

應(yīng)用：

咨詢客服

立即購買加入購物車

Anti-EFNA1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EFNA1 Antibody See all EFNA1 primary antibodies
Description:	Rabbit polyclonal antibody to EFNA1
Specificity:	The antibody detects endogenous levels of total EFNA1 protein.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from internal of human EFNA1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Tissue Specificity:	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Sequence Similarities:	Belongs to the ephrin family.
Post-Translational Modification:	Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 1942?Human Entrez Gene: 13636?Mouse Entrez Gene: 94268?Rat Omim: 191164?Human SwissProt: P20827?Human SwissProt: P52793?Mouse SwissProt: P97553?Rat Unigene: 516664?Human Unigene: 15675?Mouse Unigene: 8427?Rat
Synonyms:	B61 Antibody ECKLG Antibody EFL 1 Antibody EFL1 Antibody EFNA 1 Antibody Efna1 Antibody EFNA1_HUMAN Antibody EPH related receptor tyrosine kinase ligand 1 Antibody EPH-related receptor tyrosine kinase ligand 1 Antibody Ephrin A1 Antibody Ephrin-A1 Antibody Ephrin-A1, secreted form Antibody EphrinA1 Antibody EPLG 1 Antibody EPLG1 Antibody Immediate early response protein B61 Antibody LERK 1 Antibody LERK-1 Antibody LERK1 Antibody Ligand of eph related kinase 1 Antibody OTTHUMP00000033242 Antibody OTTHUMP00000033271 Antibody secreted form Antibody TNF alpha-induced protein 4 Antibody TNFAIP 4 Antibody TNFAIP4 Antibody Tumor necrosis factor alpha induced protein 4 Antibody Tumor necrosis factor alpha-induced protein 4 Antibody
Information:	Target information shown above is from the UniProt Consortium.