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Anti-EEF2K Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-EEF2K Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EEF2K Antibody See all EEF2K primary antibodies
Description:	Rabbit polyclonal antibody to EEF2K
Specificity:	The antibody detects endogenous level of total EEF2K protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EEF2K.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Sequence Similarities:	Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
Post-Translational Modification:	Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Database Links:	Entrez Gene: 29904?Human Entrez Gene: 13631?Mouse Entrez Gene: 25435?Rat Omim: 606968?Human SwissProt: O00418?Human SwissProt: O08796?Mouse SwissProt: P70531?Rat Unigene: 498892?Human Unigene: 25997?Mouse Unigene: 361795?Mouse Unigene: 10958?Rat
Synonyms:	C86191 Antibody Calcium/calmodulin dependent eukaryotic elongation factor 2 Antibody Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase Antibody Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase Antibody Calmodulin dependent protein kinase III Antibody cb365 Antibody EC 2.7.11.20 Antibody eEF 2 kinase Antibody eEF 2K Antibody eEF-2 kinase Antibody eEF-2K Antibody EEF2K Antibody EEF2K protein Antibody EF2K_HUMAN Antibody Elongation factor 2 kinase Antibody Eukaryotic elongation factor 2 kinase Antibody fa04b08 Antibody HSU93850 Antibody kinase eEF2K Antibody MGC45041 Antibody SMEF2K Antibody wu:fa04b08 Antibody zgc:100973 Antibody
Information:	Target information shown above is from the UniProt Consortium.