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Anti-eEF2K (phospho-S366) Antibody

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Anti-eEF2K (phospho-S366) Antibody

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Overview

Name:	Anti-eEF2K (phospho-S366) Antibody See all eEF2K primary antibodies
Description:	Rabbit polyclonal antibody to eEF2K (phospho-S366)
Specificity:	p-eEF2K (S366) pAb detects endogenous levels of eEF2K protein when phosphorylated at Ser366.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human eEF2K around the phosphorylation site of Serine 366.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 105 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Sequence Similarities:	Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
Post-Translational Modification:	Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Database Links:	Entrez Gene: 29904?Human Entrez Gene: 13631?Mouse Entrez Gene: 25435?Rat Omim: 606968?Human SwissProt: O00418?Human SwissProt: O08796?Mouse SwissProt: P70531?Rat Unigene: 498892?Human Unigene: 25997?Mouse Unigene: 361795?Mouse Unigene: 10958?Rat
Synonyms:	C86191 Antibody Calcium/calmodulin dependent eukaryotic elongation factor 2 Antibody Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase Antibody Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase Antibody Calmodulin dependent protein kinase III Antibody cb365 Antibody EC 2.7.11.20 Antibody eEF 2 kinase Antibody eEF 2K Antibody eEF-2 kinase Antibody eEF-2K Antibody EEF2K Antibody EEF2K protein Antibody EF2K_HUMAN Antibody Elongation factor 2 kinase Antibody Eukaryotic elongation factor 2 kinase Antibody fa04b08 Antibody HSU93850 Antibody kinase eEF2K Antibody MGC45041 Antibody SMEF2K Antibody wu:fa04b08 Antibody zgc:100973 Antibody
Information:	Target information shown above is from the UniProt Consortium.