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Anti-EEF2 (A50) Antibody

品牌：Antibodies

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Anti-EEF2 (A50) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EEF2 (A50) Antibody See all EEF2 primary antibodies
Description:	Rabbit polyclonal antibody to EEF2 (A50)
Specificity:	eEF2 (A50) pAb detects endogenous levels of eEF2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 20-60 of Human eEF2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 95 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Involvement in Disease:	Spinocerebellar ataxia 26: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
Sequence Similarities:	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Post-Translational Modification:	Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
Cellular Location:	Cytoplasm. Nucleus. Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.
Database Links:	Entrez Gene: 1938?Human Entrez Gene: 13629?Mouse Entrez Gene: 29565?Rat Omim: 130610?Human SwissProt: P13639?Human SwissProt: P58252?Mouse SwissProt: P05197?Rat Unigene: 515070?Human Unigene: 326799?Mouse Unigene: 379638?Mouse Unigene: 482883?Mouse Unigene: 55145?Rat
Synonyms:	EEF 2 Antibody EEF2 Antibody EF-2 Antibody EF2 Antibody EF2_HUMAN Antibody Elongation factor 2 Antibody Eukaryotic translation elongation factor 2 Antibody Polypeptidyl tRNA translocase Antibody SCA26 Antibody
Information:	Target information shown above is from the UniProt Consortium.