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Anti-EBI3 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-EBI3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-EBI3 Antibody See all EBI3 primary antibodies
Description:	Rabbit polyclonal antibody to EBI3
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 16 amino acid peptide from near the center of human EBI3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Sequence Similarities:	Belongs to the type I cytokine receptor family. Type 3 subfamily.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 10148?Human Entrez Gene: 50498?Mouse Entrez Gene: 680609?Rat Omim: 605816?Human SwissProt: Q14213?Human SwissProt: O35228?Mouse Unigene: 501452?Human Unigene: 256798?Mouse
Synonyms:	cytokine receptor Antibody EBI3 Antibody EBV induced gene 3 protein Antibody EBV-induced gene 3 protein Antibody Epstein Barr virus induced 3 Antibody Epstein Barr virus induced gene 3 Antibody Epstein Barr virus induced gene 3 protein Antibody Epstein-Barr virus-induced gene 3 protein Antibody IL 27 subunit beta Antibody IL 27B Antibody IL-27 subunit beta Antibody IL-27B Antibody IL27 subunit Antibody IL27 subunit beta Antibody IL27B Antibody IL27B_HUMAN Antibody IL35 subunit Antibody interleukin 27 subunit beta Antibody Interleukin-27 subunit beta Antibody
Information:	Target information shown above is from the UniProt Consortium.