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Anti-Dok-1 (R392) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Dok-1 (R392) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-Dok-1 (R392) Antibody See all Dok1 primary antibodies
Description:	Rabbit polyclonal antibody to Dok-1 (R392)
Specificity:	Dok-1 (R392) pAb detects endogenous levels of Dok-1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 360-408 of Human Dok-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 62 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3.
Tissue Specificity:	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequence Similarities:	Belongs to the DOK family. Type A subfamily.
Post-Translational Modification:	Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1796?Human Entrez Gene: 13448?Mouse Entrez Gene: 312477?Rat Omim: 602919?Human SwissProt: Q99704?Human SwissProt: P97465?Mouse SwissProt: Q4QQV2?Rat Unigene: 103854?Human Unigene: 156?Mouse Unigene: 117974?Rat
Synonyms:	Docking protein 1 Antibody Docking protein 1 62kD Antibody DOK 1 Antibody DOK1 Antibody DOK1_HUMAN Antibody Downstream of tyrosine kinase 1 Antibody p62(dok) Antibody P62DOK Antibody pp62 Antibody
Information:	Target information shown above is from the UniProt Consortium.