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Anti-DKK3 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-DKK3 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-DKK3 Antibody See all DKK3 primary antibodies
Description:	Rabbit polyclonal antibody to DKK3
Specificity:	DKK3 pAb detects endogenous levels of DKK3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human DKK3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~38 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Tissue Specificity:	Highest expression in heart, brain, and spinal cord.
Sequence Similarities:	Belongs to the dickkopf family.
Post-Translational Modification:	N- and O-glycosylated.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 27122?Human Entrez Gene: 50781?Mouse Entrez Gene: 171548?Rat Omim: 605416?Human SwissProt: Q9UBP4?Human SwissProt: Q9QUN9?Mouse Unigene: 292156?Human Unigene: 55143?Mouse
Synonyms:	Dickkopf 3 Antibody Dickkopf 3 homolog Antibody Dickkopf 3 homolog (Xenopus laevis) Antibody Dickkopf homolog 3 Antibody Dickkopf related protein 3 Antibody Dickkopf related protein 3 Precursor Antibody Dickkopf WNT signaling pathway inhibitor 3 Antibody Dickkopf, Xenopus, homolog of, 3 Antibody Dickkopf-3 Antibody Dickkopf-related protein 3 Antibody Dickkopf3 Antibody DKK 3 Antibody Dkk-3 Antibody Dkk3 Antibody DKK3_HUMAN Antibody hDkk 3 Antibody hDkk-3 Antibody hDkk3 Antibody Regulated in glioma Antibody REIC Antibody RIG Antibody RIG-like 5-6 Antibody RIG-like 7-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.