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Anti-DEDD2 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-DEDD2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-DEDD2 Antibody See all DEDD2 primary antibodies
Description:	Rabbit polyclonal antibody to DEDD2
Specificity:	The antibody detects endogenous levels of total DEDD2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Fusion protein of human DEDD2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification
Concentration:	0.6mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Tissue Specificity:	Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.
Cellular Location:	Nucleus > Nucleolus. Nuclear, accumulated in subnuclear structures resembling nucleoli.
Database Links:	Entrez Gene: 162989?Human Omim: 606841?Human SwissProt: Q8WXF8?Human Unigene: 515432?Human
Synonyms:	Death effector domain containing 2 Antibody Death effector domain-containing DNA-binding protein Antibody Death effector domain-containing protein Antibody Death effector domain-containing testicular protein Antibody DED containing protein FLAME 3 Antibody DEDD2 Antibody DEFT Antibody DNA binding death effector domain containing protein 2 Antibody DNA-binding death effector domain-containing protein 2 Antibody FADD like anti apoptotic molecule 3 Antibody FLAME 3 Antibody
Information:	Target information shown above is from the UniProt Consortium.