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Anti-DEAF1 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-DEAF1 Antibody

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Overview

Name:	Anti-DEAF1 Antibody See all DEAF1 primary antibodies
Description:	Rabbit polyclonal antibody to DEAF1
Specificity:	The antibody detects endogenous levels of total DEAF1 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human DEAF1 transcription factor
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
Tissue Specificity:	Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and ***** brain.
Involvement in Disease:	Mental retardation, autosomal dominant 24: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Dyskinesia, seizures, and intellectual developmental disorder: A neurodevelopmental disorder characterized by psychomotor delay, epilepsy, intellectual disability, speech impairment and dyskinesia of the limbs. Patients also manifest autistic features and other behavioral abnormalities. DYSEIDD transmission pattern is consistent with autosomal recessive inheritance.
Post-Translational Modification:	May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro).
Cellular Location:	Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.
Database Links:	Entrez Gene: 10522?Human Omim: 602635?Human SwissProt: O75398?Human Unigene: 243994?Human Unigene: 448664?Human
Synonyms:	Deaf1 Antibody DEAF1 transcription factor Antibody DEAF1_HUMAN Antibody Deformed Epidermal Autoregulatory Factor 1 Antibody Deformed epidermal autoregulatory factor 1 homolog Antibody Nuclear DEA1 related transcriptional regulator Antibody Nuclear DEAF-1-related transcriptional regulator Antibody NUDR Antibody SPN Antibody Suppressin Antibody Zinc finger MYND domain containing protein 5 Antibody Zinc finger MYND domain-containing protein 5 Antibody ZMYND5 Antibody
Information:	Target information shown above is from the UniProt Consortium.