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Anti-DDX4 Antibody

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Anti-DDX4 Antibody

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Overview

Name:	Anti-DDX4 Antibody See all DDX4 primary antibodies
Description:	Rabbit polyclonal antibody to DDX4
Specificity:	The antibody detects endogenous levels of total DDX4 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	0.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).
Tissue Specificity:	Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
Sequence Similarities:	Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Cellular Location:	Cytoplasm. Cytoplasm > Perinuclear region. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Database Links:	Entrez Gene: 54514?Human Omim: 605281?Human SwissProt: Q9NQI0?Human Unigene: 223581?Human
Synonyms:	DDX 4 Antibody Ddx4 Antibody DDX4 / MVH Antibody DDX4_HUMAN Antibody DEAD (Asp Glu Ala Asp) box polypeptide 4 Antibody DEAD box protein 4 Antibody DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 Antibody MVH Antibody Probable ATP dependent RNA helicase DDX4 Antibody Probable ATP-dependent RNA helicase DDX4 Antibody VASA Antibody Vasa homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.