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Anti-DDB1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-DDB1 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-DDB1 Antibody See all DDB1 primary antibodies
Description:	Rabbit polyclonal antibody to DDB1
Specificity:	The antibody detects endogenous level of total DDB1 protein.
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Formulation:	Supplied at 0.9mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2 (By similarity).
Sequence Similarities:	Belongs to the DDB1 family.
Post-Translational Modification:	Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis (By similarity).
Cellular Location:	Cytoplasm. Nucleus. Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (By similarity).
Database Links:	Entrez Gene: 100290337?Human Entrez Gene: 1642?Human Entrez Gene: 13194?Mouse Entrez Gene: 64470?Rat Omim: 600045?Human SwissProt: Q16531?Human SwissProt: Q3U1J4?Mouse SwissProt: Q9ESW0?Rat Unigene: 290758?Human Unigene: 289915?Mouse Unigene: 466856?Mouse Unigene: 8402?Rat
Synonyms:	Damage specific DNA binding protein 1 Antibody Damage-specific DNA-binding protein 1 Antibody DDB 1 Antibody DDB p127 subunit Antibody DDB1 Antibody DDB1_HUMAN Antibody DDBa Antibody DNA damage binding protein 1 Antibody DNA damage-binding protein 1 Antibody DNA damage-binding protein a Antibody HBV X-associated protein 1 Antibody UV damaged DNA binding factor Antibody UV damaged DNA binding protein 1 Antibody UV DDB 1 Antibody UV DDB1 Antibody UV-damaged DNA-binding factor Antibody UV-damaged DNA-binding protein 1 Antibody UV-DDB 1 Antibody X associated protein 1 Antibody XAP 1 Antibody XAP-1 Antibody XAP1 Antibody Xeroderma pigmentosum group E complementing protein Antibody Xeroderma pigmentosum group E-complementing protein Antibody XPCe Antibody XPE Antibody XPE BF Antibody XPE binding factor Antibody XPE-BF Antibody XPE-binding factor Antibody
Information:	Target information shown above is from the UniProt Consortium.