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Anti-Daxx Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-Daxx Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Daxx Antibody See all Daxx primary antibodies
Description:	Rabbit polyclonal antibody to Daxx
Applications:	E, WB, ICC
Reactivity:	Human, Mouse
Immunogen:	Raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	DEAE purified
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity).
Sequence Similarities:	Belongs to the DAXX family.
Post-Translational Modification:	Sumoylated with SUMO1 on multiple lysine residues.
Cellular Location:	Cytoplasm. Nucleus > Nucleoplasm. Nucleus > PML body. Nucleus > Nucleolus. Chromosome > Centromere. Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures.
Database Links:	Entrez Gene: 1616?Human Entrez Gene: 13163?Mouse Omim: 603186?Human SwissProt: Q9UER7?Human SwissProt: O35613?Mouse Unigene: 336916?Human Unigene: 271809?Mouse
Synonyms:	Antibody BING 2 Antibody BING2 Antibody CENP-C binding protein Antibody DAP 6 Antibody DAP6 Antibody Daxx Antibody DAXX_HUMAN Antibody Death associated protein 6 Antibody Death domain associated protein Antibody Death domain associated protein 6 Antibody Death domain-associated protein 6 Antibody EAP 1 Antibody EAP1 Antibody ETS1 associated protein 1 Antibody ETS1-associated protein 1 Antibody Fas binding protein Antibody Fas death domain associated protein Antibody Fas death domain-associated protein Antibody hDaxx Antibody MGC126245 Antibody MGC126246 Antibody
Information:	Target information shown above is from the UniProt Consortium.