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Anti-DAB2 Antibody

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Anti-DAB2 Antibody

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Overview

Name:	Anti-DAB2 Antibody See all DAB2 primary antibodies
Description:	Rabbit polyclonal antibody to DAB2
Specificity:	The antibody detects endogenous levels of total DAB2 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.
Tissue Specificity:	Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).
Post-Translational Modification:	Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity).
Cellular Location:	Cytoplasm. Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Membrane > Clathrin-coated pit. Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
Database Links:	Entrez Gene: 1601?Human Omim: 601236?Human SwissProt: P98082?Human Unigene: 696631?Human
Synonyms:	DAB 2 Antibody Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) Antibody DAB2 Antibody Differentially expressed in ovarian cancer 2 Antibody Differentially expressed protein 2 Antibody Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein) Antibody Disabled homolog 2 Antibody Disabled homolog 2 mitogen responsive phosphoprotein Antibody Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila) Antibody Disabled, Drosophila, homolog of, 2 Antibody DOC 2 Antibody DOC2 Antibody FLJ26626 Antibody Mitogen responsive phosphoprotein Antibody
Information:	Target information shown above is from the UniProt Consortium.