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Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody

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Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody

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Overview

Name:	Anti-Cytokeratin 8 (Acetyl-Lys483) Antibody See all Cytokeratin 8 primary antibodies
Description:	Rabbit polyclonal antibody to Cytokeratin 8 (Acetyl-Lys483)
Specificity:	Acetyl-Cytokeratin 8 (K483) Polyclonal Antibody detects endogenous levels of Cytokeratin 8 protein only when acetylated at K483.
Applications:	WB, ELISA
Reactivity:	Human
Immunogen:	Synthesized peptide derived from the human Cytokeratin 8 around the acetylation site of K483.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue Specificity:	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Involvement in Disease:	Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Cellular Location:	Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
Database Links:	Entrez Gene: 3856?Human Omim: 148060?Human SwissProt: P05787?Human Unigene: 533782?Human Unigene: 708445?Human
Synonyms:	CARD2 Antibody CK 8 Antibody CK-8 Antibody CK8 Antibody CYK8 Antibody CYKER Antibody Cytokeratin 8 Antibody Cytokeratin endo A Antibody Cytokeratin-8 Antibody DreK8 Antibody EndoA Antibody K2C8 Antibody K2C8_HUMAN Antibody K8 Antibody Keratin 8 Antibody Keratin type II cytoskeletal 8 Antibody Keratin, type II cytoskeletal 8 Antibody Keratin-8 Antibody KO Antibody Krt 2.8 Antibody KRT8 Antibody MGC118110 Antibody MGC174782 Antibody MGC53564 Antibody MGC85764 Antibody sb:cb186 Antibody Type-II keratin Kb8 Antibody
Information:	Target information shown above is from the UniProt Consortium.