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Anti-Cytokeratin 18 (phospho-S52) Antibody

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Anti-Cytokeratin 18 (phospho-S52) Antibody

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規(guī)格：50μl

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Anti-Cytokeratin 18 (phospho-S52) Antibody

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Overview

Name:	Anti-Cytokeratin 18 (phospho-S52) Antibody See all Cytokeratin 18 primary antibodies
Description:	Rabbit polyclonal antibody to Cytokeratin 18 (phospho-S52)
Specificity:	p-Cytokeratin 18 (S52) pAb detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at Ser52. (removal of the initiator methionine)
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human Cytokeratin 18 around the phosphorylation site of Serine 53.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 46 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue Specificity:	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in Disease:	Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Cellular Location:	Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
Database Links:	Entrez Gene: 3875?Human Entrez Gene: 16668?Mouse Entrez Gene: 294853?Rat Omim: 148070?Human SwissProt: P05783?Human SwissProt: P05784?Mouse SwissProt: Q5BJY9?Rat Unigene: 406013?Human Unigene: 22479?Mouse Unigene: 103924?Rat
Synonyms:	Cell proliferation inducing gene 46 protein Antibody Cell proliferation inducing protein 46 Antibody Cell proliferation-inducing gene 46 protein Antibody CK 18 Antibody CK-18 Antibody CK18 Antibody CYK 18 Antibody CYK18 Antibody Cytokeratin 18 Antibody Cytokeratin endo B Antibody Cytokeratin-18 Antibody K 18 Antibody K18 Antibody K1C18_HUMAN Antibody KA18 Antibody Keratin 18 Antibody Keratin 18, type I Antibody Keratin D Antibody keratin, type I cytoskeletal 18 Antibody Keratin-18 Antibody Krt18 Antibody
Information:	Target information shown above is from the UniProt Consortium.