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Anti-Cytochrome P450 3A4 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cytochrome P450 3A4 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Cytochrome P450 3A4 Antibody See all Cytochrome P450 3A4 primary antibodies
Description:	Rabbit polyclonal antibody to Cytochrome P450 3A4
Specificity:	The antibody detects endogenous levels of total Cytochrome P450 3A4 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human Cytochrome P450 3A4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
Tissue Specificity:	Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Sequence Similarities:	Belongs to the cytochrome P450 family.
Post-Translational Modification:	Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
Cellular Location:	Endoplasmic reticulum membrane. Microsome membrane.
Database Links:	Entrez Gene: 1576?Human Omim: 124010?Human SwissProt: P08684?Human Unigene: 728751?Human
Synonyms:	1,8-cineole 2-exo-monooxygenase Antibody Albendazole monooxygenase Antibody Albendazole sulfoxidase Antibody CP33 Antibody CP34 Antibody CP3A4_HUMAN Antibody CYP3 Antibody CYP3A Antibody CYP3A3 Antibody CYP3A4 Antibody CYPIIIA3 Antibody CYPIIIA4 Antibody Cytochrome P450 3A3 Antibody Cytochrome P450 3A4 Antibody Cytochrome P450 family 3 subfamily A polypeptide 4 Antibody Cytochrome P450 HLp Antibody Cytochrome P450 NF-25 Antibody Cytochrome P450 subfamily IIIA polypeptide 4 Antibody cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 Antibody cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Antibody Cytochrome P450-PCN1 Antibody Glucocorticoid inducible P450 Antibody HLP Antibody MGC126680 Antibody NF 25 Antibody NF25 Antibody Nifedipine oxidase Antibody P450 III steroid inducible Antibody P450 PCN1 Antibody P450, family III Antibody P450C3 Antibody P450PCN1 Antibody Quinine 3 monooxygenase Antibody Quinine 3-monooxygenase Antibody Taurochenodeoxycholate 6 alpha hydroxylase Antibody Taurochenodeoxycholate 6-alpha-hydroxylase Antibody
Information:	Target information shown above is from the UniProt Consortium.