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Anti-Cystatin C Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-Cystatin C Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Cystatin C Antibody See all Cystatin C primary antibodies
Description:	Mouse monoclonal (KT145) antibody to Cystatin C.
Applications:	WB, ELISA, sELISA
Reactivity:	Human
Immunogen:	Purified native human Cystatin-C.
Host:	Mouse
Clonality:	Monoclonal
Clone:	KT145
Isotype:	IgG2a
Conjugate:	Unconjugated
Purification:	IgG is purified through a Protein A column.
Concentration:	1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Tissue Specificity:	Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
Involvement in Disease:	Amyloidosis 6: A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Macular degeneration, age-related, 11: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequence Similarities:	Belongs to the cystatin family.
Post-Translational Modification:	The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 1471?Human Omim: 604312?Human SwissProt: P01034?Human Unigene: 304682?Human
Synonyms:	AD 8 Antibody AD8 Antibody Amyloid angiopathy and cerebral hemorrhage Antibody ARMD11 Antibody bA218C14.4 Antibody bA218C14.4 (cystatin C) Antibody Cst 3 Antibody Cst3 Antibody CST3 protein Antibody Cystatin 3 Antibody Cystatin C Antibody Cystatin-3 Antibody Cystatin-C Antibody Cystatin3 Antibody CystatinC Antibody CYTC_HUMAN Antibody Epididymis secretory protein Li 2 Antibody Gamma trace Antibody Gamma-trace Antibody HCCAA Antibody HEL S 2 Antibody MGC117328 Antibody Neuroendocrine basic polypeptide Antibody Post gamma globulin Antibody Post-gamma-globulin Antibody
Information:	Target information shown above is from the UniProt Consortium.