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Anti-Cyclophilin F (Y121) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cyclophilin F (Y121) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Cyclophilin F (Y121) Antibody See all Cyclophilin F primary antibodies
Description:	Rabbit polyclonal antibody to Cyclophilin F (Y121)
Specificity:	Cyclophilin F (Y121) pAb detects endogenous levels of Cyclophilin F protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 91-140 of Human Cyclophilin F.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 22 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Sequence Similarities:	Belongs to the cyclophilin-type PPIase family.
Post-Translational Modification:	Deacteylated at Lys-167 by SIRT3.
Cellular Location:	Mitochondrion matrix.
Database Links:	Entrez Gene: 10105?Human Entrez Gene: 105675?Mouse Entrez Gene: 282819?Rat Omim: 604486?Human SwissProt: P30405?Human SwissProt: Q99KR7?Mouse SwissProt: P29117?Rat Unigene: 381072?Human Unigene: 41656?Mouse Unigene: 2923?Rat
Synonyms:	Cyclophilin 3 Antibody cyclophilin D Antibody Cyclophilin F Antibody Cyp D Antibody CyP M Antibody CYP3 Antibody CypD Antibody hCyP3 Antibody mitochondrial Antibody Mitochondrial cyclophilin Antibody Peptidyl prolyl cis trans isomerase, mitochondral Antibody Peptidyl-prolyl cis-trans isomerase F Antibody Peptidyl-prolyl cis-trans isomerase F, mitochondrial Antibody Peptidylprolyl isomerase F Antibody Peptidylprolyl isomerase F (cyclophilin F) Antibody PPIase Antibody PPIase F Antibody Ppif Antibody PPIF_HUMAN Antibody Rotamase Antibody Rotamase F Antibody
Information:	Target information shown above is from the UniProt Consortium.