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Anti-Cyclin L1 (E491) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cyclin L1 (E491) Antibody

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Name:	Anti-Cyclin L1 (E491) Antibody See all Cyclin L1 primary antibodies
Description:	Rabbit polyclonal antibody to Cyclin L1 (E491)
Specificity:	Cyclin-L1 (E491) pAb detects endogenous levels of Cyclin-L1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 460-518 of Human Cyclin L1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).
Tissue Specificity:	Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Sequence Similarities:	Belongs to the cyclin family. Cyclin L subfamily.
Cellular Location:	Nucleus speckle. Nucleus > Nucleoplasm. Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Database Links:	Entrez Gene: 57018?Human Entrez Gene: 56706?Mouse Entrez Gene: 114121?Rat Omim: 613384?Human SwissProt: Q9UK58?Human SwissProt: Q52KE7?Mouse SwissProt: Q9R1Q2?Rat Unigene: 4859?Human Unigene: 175612?Mouse Unigene: 12962?Rat
Synonyms:	Ania 6a Antibody CCNL1 Antibody CCNL1_HUMAN Antibody Cyclin L Antibody Cyclin L gamma Antibody Cyclin L1 Antibody Cyclin-L Antibody Cyclin-L1 Antibody
Information:	Target information shown above is from the UniProt Consortium.