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Anti-CYB5R3 (I169) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CYB5R3 (I169) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CYB5R3 (I169) Antibody See all CYB5R3 primary antibodies
Description:	Rabbit polyclonal antibody to CYB5R3 (I169)
Specificity:	CYB5R3 (I169) pAb detects endogenous levels of CYB5R3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide, corresponding to amino acids 141-190 of Human CYB5R3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 34 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Tissue Specificity:	Isoform 2 is expressed at late stages of erythroid maturation.
Involvement in Disease:	Methemoglobinemia CYB5R3-related: A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
Sequence Similarities:	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Cellular Location:	Endoplasmic reticulum membrane. Mitochondrion outer membrane.
Database Links:	Entrez Gene: 1727?Human Entrez Gene: 109754?Mouse Omim: 613213?Human SwissProt: P00387?Human SwissProt: Q9DCN2?Mouse Unigene: 561064?Human Unigene: 22560?Mouse
Synonyms:	B5R Antibody CYB5R3 Antibody Cytochrome b5 reductase Antibody Cytochrome b5 reductase 3 Antibody DIA1 Antibody Diaphorase 1 Antibody Diaphorase-1 Antibody NADH cytochrome b5 reductase 3 Antibody NADH-cytochrome b5 reductase 3 membrane-bound form Antibody NADH-cytochrome b5 reductase 3 soluble form Antibody NB5R3_HUMAN Antibody OTTHUMP00000028761 Antibody OTTHUMP00000198435 Antibody OTTHUMP00000198574 Antibody OTTHUMP00000198662 Antibody OTTHUMP00000198665 Antibody
Information:	Target information shown above is from the UniProt Consortium.