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Anti-CTCFL Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CTCFL Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-CTCFL Antibody See all CTCFL primary antibodies
Description:	Rabbit polyclonal antibody to CTCFL.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CTCFL.
Protein Length:	663
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Tissue Specificity:	Testis specific. Specifically expressed in primary spermatocytes.
Sequence Similarities:	Belongs to the CTCF zinc-finger protein family.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 140690?Human Entrez Gene: 664799?Mouse Entrez Gene: 100360757?Rat Omim: 607022?Human SwissProt: Q8NI51?Human SwissProt: A2APF3?Mouse Unigene: 131543?Human Unigene: 389396?Mouse
Synonyms:	BORIS Antibody BORIS like protein Antibody Brother of the regulator of imprinted sites Antibody Cancer/testis antigen 27 Antibody CCCTC binding factor (zinc finger protein) like Antibody CCCTC-binding factor Antibody CT27 Antibody CTCF paralog Antibody CTCF T Antibody CTCF-like protein Antibody Ctcfl Antibody CTCFL_HUMAN Antibody dJ579F20.2 Antibody HMG 1L1 Antibody HMGB1L1 Antibody MGC163358 Antibody MGC169105 Antibody MGC169106 Antibody Putative high mobility group protein 1 like 1 Antibody Putative high mobility group protein B1 like 1 Antibody Transcriptional repressor CTCFL Antibody Zinc finger protein CTCF-T Antibody
Information:	Target information shown above is from the UniProt Consortium.