Synthetic peptide corresponding to Human CSTB (C terminal).
Sequence:
C-QTNKAKHDELTYF
Host:
Goat
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:
100 μg at 0.5 mg/ml.
Product Form:
Liquid
Formulation:
Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Involvement in Disease:
Epilepsy, progressive myoclonic 1: An autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop.
Sequence Similarities:
Belongs to the cystatin family.
Cellular Location:
Cytoplasm. Nucleus.
Database Links:
Entrez Gene: 1476?Human
Omim: 601145?Human
SwissProt: P04080?Human
Unigene: 695?Human
Synonyms:
CHROW21 Antibody
CPI B Antibody
CPI-B Antibody
CST 6 Antibody
CST6 Antibody
CSTB Antibody
Cystatin B Antibody
Cystatin B (stefin B) Antibody
Cystatin-B Antibody
CYTB Antibody
CYTB_HUMAN Antibody
EPM1 Antibody
EPM1A Antibody
Liver thiol proteinase inhibitor Antibody
PME Antibody
Stefin B Antibody
Stefin-B Antibody
STF B Antibody
STFB Antibody
ULD Antibody
Information:
Target information shown above is from the UniProt Consortium.