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Anti-CSPG4 Antibody

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Anti-CSPG4 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CSPG4 Antibody See all CSPG4 primary antibodies
Description:	Rabbit polyclonal antibody to CSPG4
Specificity:	The antibody detects endogenous levels of total CSPG4 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.6mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
Tissue Specificity:	Detected only in malignant melanoma cells.
Post-Translational Modification:	O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
Cellular Location:	Cell membrane. Apical cell membrane. Cell projection > Lamellipodium membrane. Cell surface. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).
Database Links:	Entrez Gene: 1464?Human Entrez Gene: 121021?Mouse Entrez Gene: 81651?Rat Omim: 601172?Human SwissProt: Q6UVK1?Human SwissProt: Q8VHY0?Mouse SwissProt: Q00657?Rat Unigene: 513044?Human Unigene: 41329?Mouse Unigene: 10381?Rat
Synonyms:	4732461B14Rik Antibody AN2 Antibody AN2 proteoglycan Antibody Chondroitin sulfate proteoglycan 4 Antibody Chondroitin sulfate proteoglycan 4 (melanoma-associated) Antibody Chondroitin sulfate proteoglycan NG2 Antibody Cspg4 Antibody Cspg4 chondroitin sulfate proteoglycan 4 Antibody CSPG4_HUMAN Antibody HMW-MAA Antibody HSN tumor-specific antigen Antibody Kiaa4232 Antibody MCSP Antibody MCSPG Antibody MEL-CSPG Antibody Melanoma chondroitin sulfate proteoglycan Antibody Melanoma-associated chondroitin sulfate proteoglycan Antibody MELCSPG Antibody MSK16 Antibody NG2 Antibody
Information:	Target information shown above is from the UniProt Consortium.