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Anti-CRMP-2 (Phospho-Thr509) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CRMP-2 (Phospho-Thr509) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-CRMP-2 (Phospho-Thr509) Antibody See all CRMP-2 primary antibodies
Description:	Rabbit polyclonal antibody to CRMP-2 (Phospho-Thr509)
Specificity:	The antibody detects endogenous levels of CRMP-2 only when phosphorylated at threonine 509.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity:	Human
Immunogen:	Peptide sequence around phosphorylation site of threonine 509 (S-V-T(p)-P-K) derived from Human CRMP-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Post-Translational Modification:	3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Cellular Location:	Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Membrane. Tightly but non-covalently associated with membranes.
Database Links:	Entrez Gene: 1808?Human Omim: 602463?Human SwissProt: Q16555?Human Unigene: 173381?Human Unigene: 593187?Human
Synonyms:	Collapsin response mediator protein Antibody Collapsin response mediator protein 2 Antibody Collapsin response mediator protein hCRMP 2 Antibody CRAM Antibody CRMP 2 Antibody CRMP-2 Antibody CRMP2 Antibody DHPRP 2 Antibody DHPRP2 Antibody Dihydropyrimidinase 2 Antibody Dihydropyrimidinase like 2 Antibody Dihydropyrimidinase like 2 long form Antibody Dihydropyrimidinase related protein 2 Antibody Dihydropyrimidinase-related protein 2 Antibody DPYL 2 Antibody DPYL2 Antibody DPYL2_HUMAN Antibody DPYSL 2 Antibody Dpysl2 Antibody DRP-2 Antibody DRP2 Antibody Musunc 33 Antibody Musunc33 Antibody N2A3 Antibody TOAD 64 Antibody TOAD64 Antibody ULIP 2 protein Antibody ULIP-2 Antibody Ulip2 Antibody Unc-33-like phosphoprotein 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.