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Anti-Crk2 (P215) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Crk2 (P215) Antibody

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Name:	Anti-Crk2 (P215) Antibody See all Crk2 primary antibodies
Description:	Rabbit polyclonal antibody to Crk2 (P215)
Specificity:	Crk2 (P215) pAb detects endogenous levels of Crk2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 200-250 of Human Crk2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Function:	Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Sequence Similarities:	Belongs to the CRK family.
Post-Translational Modification:	Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
Cellular Location:	Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion.