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Anti-CREB (phospho-S142) Antibody

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Anti-CREB (phospho-S142) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CREB (phospho-S142) Antibody See all CREB primary antibodies
Description:	Rabbit polyclonal antibody to CREB (phospho-S142)
Specificity:	p-CREB (S142) pAb detects endogenous levels of CREB protein only when phosphorylated at Ser142
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 142.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 38 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Involvement in Disease:	Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1385?Human Entrez Gene: 12912?Mouse Entrez Gene: 81646?Rat Omim: 123810?Human SwissProt: P16220?Human SwissProt: Q01147?Mouse SwissProt: P15337?Rat Unigene: 516646?Human Unigene: 453295?Mouse Unigene: 90061?Rat
Synonyms:	Active transcription factor CREB Antibody cAMP response element binding protein Antibody cAMP response element binding protein 1 Antibody cAMP responsive element binding protein 1 Antibody cAMP-responsive element-binding protein 1 Antibody CREB Antibody CREB-1 Antibody CREB1 Antibody CREB1_HUMAN Antibody Cyclic AMP-responsive element-binding protein 1 Antibody MGC9284 Antibody OTTHUMP00000163864 Antibody OTTHUMP00000163865 Antibody OTTHUMP00000206660 Antibody OTTHUMP00000206662 Antibody OTTHUMP00000206667 Antibody Transactivator protein Antibody
Information:	Target information shown above is from the UniProt Consortium.