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Anti-Cortactin (Phospho-Tyr466) Antibody

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Anti-Cortactin (Phospho-Tyr466) Antibody

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規(guī)格：50μl

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Anti-Cortactin (Phospho-Tyr466) Antibody

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Overview

Name:	Anti-Cortactin (Phospho-Tyr466) Antibody See all Cortactin primary antibodies
Description:	Rabbit polyclonal antibody to Cortactin (Phospho-Tyr466)
Specificity:	The antibody detects endogenous level of Cortactin only when phosphorylated at tyrosine 466.
Applications:	WB
Dilutions:	Western blotting: 1:500~1:1000
Reactivity:	Human, Mouse
Immunogen:	Peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Predicted MW:	85kd
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Post-Translational Modification:	Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
Cellular Location:	Cytoplasm > Cytoskeleton. Cell projection > Lamellipodium. Cell projection > Ruffle. Cell projection > Dendrite. Cell projection. Cell membrane. Cell projection > Podosome. Cell junction. Cell junction > Focal adhesion. Membrane > Clathrin-coated pit. Cell projection > Dendritic spine. Cytoplasm > Cell cortex. Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).
Database Links:	Entrez Gene: 2017?Human Entrez Gene: 13043?Mouse GenBank: NM_138565?Human GenBank: NM_007803?Mouse Omim: 164765?Human SwissProt: Q14247?Human SwissProt: Q60598?Mouse Unigene: 596164?Human Unigene: 205601?Mouse
Synonyms:	Amplaxin Antibody Cortactin Antibody CTTN Antibody EMS 1 Antibody EMS1 Antibody FLJ34459 Antibody Mammary tumor and squamous cell carcinoma associated Antibody Oncogene EMS1 Antibody p80/85 src substrate Antibody Src substrate cortactin Antibody SRC8_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.