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Anti-Cleaved-Caspase-9 p35 (D315) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-Cleaved-Caspase-9 p35 (D315) Antibody

商品詳情參考文獻相關(guān)資料

Name:	Anti-Cleaved-Caspase-9 p35 (D315) Antibody See all Cleaved-Caspase-9 p35 primary antibodies
Description:	Rabbit polyclonal antibody to Cleaved-Caspase-9 p35 (D315)
Specificity:	Cleaved-Caspase-9 p35 (D315) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p35 protein resulting from cleavage adjacent to D315.
Applications:	WB, IHC, IF, ELISA
Reactivity:	Human
Immunogen:	Synthesized peptide derived from the Internal region of human Caspase-9 p35.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity:	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.