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Anti-CIITA Antibody

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規(guī)格：100μl

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Anti-CIITA Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CIITA Antibody See all CIITA primary antibodies
Description:	Rabbit polyclonal antibody to CIITA
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 16 amino acid peptide near the amino terminus of human CIITA.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity).
Tissue Specificity:	Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and at very low levels in dendritic cells.
Post-Translational Modification:	Autophosphorylated, affecting interaction with TAF7.
Cellular Location:	Nucleus. Nucleus > PML body. Recruited to PML body by PML.
Database Links:	Entrez Gene: 4261?Human Entrez Gene: 12265?Mouse Entrez Gene: 85483?Rat Omim: 600005?Human SwissProt: P33076?Human SwissProt: P79621?Mouse Unigene: 701991?Human Unigene: 249560?Mouse Unigene: 453401?Mouse Unigene: 483581?Mouse Unigene: 16740?Rat
Synonyms:	C2TA Antibody C2TA_HUMAN Antibody CIITA Antibody CIITA IV Antibody Class II major histocompatibility complex transactivator Antibody Class II transactivator Antibody MHC class II transactivator Antibody MHC class II transactivator type III Antibody MHC2TA Antibody NLR family acid domain containing Antibody NLRA Antibody Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing Antibody
Information:	Target information shown above is from the UniProt Consortium.