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Anti-CIDEC Antibody

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Anti-CIDEC Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CIDEC Antibody See all CIDEC primary antibodies
Description:	Rabbit polyclonal antibody to CIDEC
Specificity:	The antibody detects endogenous levels of total CIDEC protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Tissue Specificity:	Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
Involvement in Disease:	Lipodystrophy, familial partial, 5: A form of lipodystrophy characterized by loss of subcutaneous adipose tissue affecting limb, femorogluteal and subcutaneous abdominal fat, preservation of visceral, neck and axilliary fat, hepatomegaly, hepatic steatosis and insulin-resistant diabetes.
Post-Translational Modification:	Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity).
Cellular Location:	Nucleus. Endoplasmic reticulum. Lipid droplet. Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
Database Links:	Entrez Gene: 63924?Human Entrez Gene: 14311?Mouse Omim: 612120?Human SwissProt: Q96AQ7?Human SwissProt: P56198?Mouse Unigene: 567562?Human Unigene: 635072?Human Unigene: 10026?Mouse
Synonyms:	Cell death activator Antibody Cell death activator CIDE-3 Antibody Cell death inducing DFFA like effector C Antibody Cell death inducing DFFA like effector protein C Antibody Cell death-inducing DFFA-like effector protein C Antibody CIDE 3 Antibody CIDE C Antibody CIDE3 Antibody CIDEC Antibody CIDEC_HUMAN Antibody Fat specific protein 27 Antibody Fat-specific protein FSP27 homolog Antibody FLJ20871 Antibody FPLD5 Antibody FSP27 Antibody
Information:	Target information shown above is from the UniProt Consortium.